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Granulomatosis with Polyangiitis

Also called: GPA, Wegener's Granulomatosis

Summary

Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. It is a type of vasculitis, or inflammation of the blood vessels. The inflammation limits the flow of blood to important organs, causing damage. It can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs, and kidneys.

The cause of GPA is unknown. It can affect people at any age. Men and women are equally affected. It is more common in whites. Symptoms may include joint pain, weakness, tiredness, and cold symptoms such as a runny nose that doesn't get better. Doctors use blood tests, chest X-rays, and biopsies to diagnose GPA and rule out other causes of the symptoms.

Early treatment is important. Most people improve with medicines to slow or stop the inflammation.

NIH: National Institute of Allergy and Infectious Diseases

Start Here

  • (American College of Rheumatology) Also in
  • (Johns Hopkins Vasculitis Center)

Symptoms

  • (Mayo Foundation for Medical Education and Research)

Diagnosis and Tests

Treatments and Therapies

  • (Johns Hopkins Vasculitis Center)

Genetics

  • From the National Institutes of Health (National Library of Medicine)

Clinical Trials

  • From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

Reference Desk

  • (Vasculitis Foundation)

Patient Handouts

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