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Charcot-Marie-Tooth Disease

Also called: Hereditary motor and sensory neuropathy, Peroneal muscular atrophy
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Summary

Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders. It is named after the three doctors who first identified it. In the United States, CMT affects about 1 in 2,500 people.

CMT affects your peripheral nerves. Peripheral nerves carry movement and sensation signals between the brain and spinal cord and the rest of the body. Symptoms usually start around the teen years. Foot problems such as high arches or hammertoes can be early symptoms. As CMT progresses, your lower legs may weaken. Later, your hands may also become weak.

Doctors diagnose CMT by doing a neurologic exam, nerve tests, genetic tests, or a nerve biopsy. There is no cure. The disease can be so mild you don't realize you have it or severe enough to make you weak. Physical therapy, occupational therapy, braces and other devices and sometimes surgery can help.

NIH: National Institute of Neurological Disorders and Stroke

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  • (Muscular Dystrophy Association) - PDF Also in
  • From the National Institutes of Health (National Institute of Neurological Disorders and Stroke) - Short Summary
  • From the National Institutes of Health (National Institute of Neurological Disorders and Stroke) Also in

Symptoms

  • (Muscular Dystrophy Association)

Living With

  • (Muscular Dystrophy Association)

Related Issues

  • From the National Institutes of Health (National Institute of Neurological Disorders and Stroke) Also in

Specifics

  • (Muscular Dystrophy Association)

Genetics

  • (Muscular Dystrophy Association)
  • From the National Institutes of Health (National Library of Medicine)
  • From the National Institutes of Health (National Human Genome Research Institute)

Clinical Trials

  • From the National Institutes of Health (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

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  • (American Academy of Neurology)
  • From the National Institutes of Health Also in

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